Table 3.
Multivariable analysis of the association between prolonged lymphopenia and death outcome.
| Risk factors | Influenza |
SARS-CoV-2 |
Other respiratory viruses |
|||
|---|---|---|---|---|---|---|
| OR (95 % CI) | p | OR (95 % CI) | p | OR (95 % CI) | p | |
| Duration of lymphopenia | ||||||
| 1–2 days | Reference | Reference | Reference | |||
| 3–7 days | 7.20 (2.27–22.77) | 0.0008 | 3.07 (1.89–5.01) | <0.0001 | 1.61 (0.46–5.66) | 0.4538 |
| More than 7 days | 17.80 (5.21–60.82) | <0.0001 | 6.28 (3.53–11.18) | <0.0001 | 3.23 (0.79–13.21) | 0.1031 |
| Length of stay | 0.96 (0.93–1.01) | 0.0862 | 0.85 (0.81–0.89) | <0.0001 | 0.92 (0.85–1.00) | 0.0417 |
| Age >65 years | 1.05 (0.50–2.22) | 0.8988 | 2.06 (1.34–3.17) | 0.0009 | 2.52 (0.92–6.94) | 0.0737 |
| Corticosteroids | 2.08 (1.04–4.15) | 0.0371 | 1.33 (0.91–1.93) | 0.1360 | 3.07 (1.05–8.99) | 0.0406 |
| Chronic kidney disease | 2.37 (1.04–5.38) | 0.0395 | 1.52 (0.96–2.43) | 0.0768 | 6.04 (1.92–19.01) | 0.0021 |
| Chronic respiratory disease | 0.83 (0.37–1.85) | 0.6526 | 1.33 (0.90–1.98) | 0.1512 | 1.01 (0.38–2.71) | 0.9782 |
| Cardiovascular disease | 0.84 (0.40–1.77) | 0.6397 | 3.19 (2.21–4.60) | <0.0001 | 1.45 (0.52–3.99) | 0.4765 |
| Lymphopenia on admission | 0.78 (0.27–2.25) | 0.6392 | 0.88 (0.46–1.67) | 0.6909 | 0.54 (0.13–2.20) | 0.3926 |
Notes. P values, odds ratios and 95 % confidence intervals were estimated by Logistic regression. Other respiratory viruses included respiratory syncytial virus, parainfluenza virus, human rhinovirus, coronavirus, human metapneumovirus and adenovirus.
Abbreviations: OR, odds ratio; CI, confidence interval.