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. 2024 May 30;39(2):282–293. doi: 10.4266/acc.2024.00612

Table 2.

Summary of the main values in therapeutic hypothermia

Study Total number Intervention Control Aneurysm secured method Target temperature (℃) Induction time Hypothermia time Rewarming rate Hypothermia method Interval from onset to cooling Shivering control system
Muroi et al. (2008) [13] 15 7 8 NA 33 NA NA NA Endovascular cooling NA Yes
Neuman et al. (2008) [14] 37 25 12 Coil 34 <3 hr >72 hr Passive warming Surface cooling Mixed (immediately or after admission 4–5 days) No
Anei et al. (2010) [15] 35 19 16 Clip or coil 34 NA 48 hr 1 °C/day Surface cooling <24 No
Karnatovskaia et al. (2014) [16] 35 19 16 Clip or coil 32–34 NA >48 hr <0.5 °C/hr Surface cooling NA No
Kuramatsu et al. (2015) [17] 36 12 24 Clip or coil 35 NA 7±1 day 0.5 °C/day Endovascular cooling <48 Yes
Choi et al. (2017) [18] 22 11 11 Clip or coil 34.5 <1 hr 48 1 °C/day Endovascular or surface cooling <12 Yes
Shui et al. (2018) [19] 62 30 32 NA 35 4–12 hr 5–7 day 1 °C/hr Surface cooling 2–8 hr No
Rhim et al. (2022) [20] 54 18 36 Coil 34–35 NA 5 day 0.5 °C/day Surface cooling <8 Yes
Won et al. (2022) [21] 72 25 47 Clip or coil 34.5 <1 hr 48 hr 1 °C/day Endovascular or surface cooling NA Yes

NA: not available.