Table 3.
Outcome | Anticipated absolute effectsa) (95% CI) |
RR (95% CI) | No. of participants (studies) | Certainty of the evidence (GRADE) | |
---|---|---|---|---|---|
Risk with standard care | Risk with therapeutic hypothermia | ||||
Unfavorable function outcome | 740 Per 1,000 | 644 Per 1,000 (496–836) | 0.87 (0.67–1.13) | 271 (7 Studies) | ⨁◯◯◯ |
Very low | |||||
Vasospasm | 466 Per 1,000 | 294 Per 1,000 (191–447) | 0.63 (0.41–0.96) | 174 (4 Studies) | ⨁◯◯◯ |
Very low | |||||
Delayed cerebral ischemia | 451 Per 1,000 | 370 Per 1,000 (212–654) | 0.82 (0.47–1.45) | 130 (3 Studies) | ⨁◯◯◯ |
Very low | |||||
Hydrocephalus | 293 Per 1,000 | 334 Per 1,000 (184–609) | 1.14 (0.63–2.08) | 130 (3 Studies) | ⨁◯◯◯ |
Very low | |||||
Mortality | 336 Per 1,000 | 249 Per 1,000 (118–524) | 0.74 (0.35–1.56) | 219 (5 Studies) | ⨁◯◯◯ |
Very low |
GRADE: Grading of Recommendations Assessment, Development and Evaluation; CI: confidence interval; RR: risk ratio (relative effect).
The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).