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. 2024 May 30;39(2):282–293. doi: 10.4266/acc.2024.00612

Table 3.

Summary of findings table using the GRADE methodology for outcomes comparing therapeutic hypothermia to standard care in poor grade subarachnoid hemorrhage

Outcome Anticipated absolute effectsa) (95% CI)
RR (95% CI) No. of participants (studies) Certainty of the evidence (GRADE)
Risk with standard care Risk with therapeutic hypothermia
Unfavorable function outcome 740 Per 1,000 644 Per 1,000 (496–836) 0.87 (0.67–1.13) 271 (7 Studies) ⨁◯◯◯
Very low
Vasospasm 466 Per 1,000 294 Per 1,000 (191–447) 0.63 (0.41–0.96) 174 (4 Studies) ⨁◯◯◯
Very low
Delayed cerebral ischemia 451 Per 1,000 370 Per 1,000 (212–654) 0.82 (0.47–1.45) 130 (3 Studies) ⨁◯◯◯
Very low
Hydrocephalus 293 Per 1,000 334 Per 1,000 (184–609) 1.14 (0.63–2.08) 130 (3 Studies) ⨁◯◯◯
Very low
Mortality 336 Per 1,000 249 Per 1,000 (118–524) 0.74 (0.35–1.56) 219 (5 Studies) ⨁◯◯◯
Very low

GRADE: Grading of Recommendations Assessment, Development and Evaluation; CI: confidence interval; RR: risk ratio (relative effect).

a)

The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).