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. 2024 May 16;27(6):110011. doi: 10.1016/j.isci.2024.110011

Figure 8.

Figure 8

Synergy genes are sensitive to combined p300/CBP and BET Bromodomain inhibition

(A–C) 3D bar plots of normalized transcript counts for CXCL9 (A), CXCL10 (B), and CXCL11 (C) with the indicated amounts of A-485 and/or JQ1 (n = 3 per condition).

(D–F) Bar plots listing supernatant concentrations of CXCL9 (D) CXCL10 (E) and CXCL11 (F) in IFNγ/TNFα + Vehicle-treated cells or with costimulation across various concentrations of A-485 and/or JQ1. A one-way ANOVA followed by Dunnett’s test was performed to assess statistical significance. Data shown are mean ± SD (n = 3 per condition). ∗p < 0.05 ∗∗∗∗p ≤ 0.0001.