REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
p65 (Rabbit)	Active Motif (39369)	RRID:AB_2793231
Beta Actin Mouse (Monoclonal)	ThermoFisher (Clone 15G5A/E2) (MA1-140) (Lot: TK276375)	RRID:AB_2536844
STAT1 (Rabbit)	Cell Signaling Technology (14995) (Lot:4)	RRID:AB_2716280
Goat anti-Rabbit Alexa Fluor™ 594	Thermo Fisher Scientific (A-11037) (Lot: 1777945)	RRID:AB_2534095
Goat anti-mouse Alexa Fluor™ 488	Thermo Fisher Scientific (A-21121) (Lot: 1704461)	RRID:AB_2535764
Rabbit IgG	Diagenode (C15410206) (Lot: RIG001AP )	RRID:AB_2722554
Rabbit monoclonal p65 (D14E12)	Cell Signaling Technology (8242) (Lot: 8242S)	RRID:AB_10859369
Rabbit monoclonal STAT1 (D4Y6Z)	Cell Signaling Technology (14995) (Lot: 4)	RRID:AB_2716280
Goat anti-Rabbit Alexa Fluor™ 647	ThermoFisher (A-21244) (Lot: 2247991)	RRID:AB_2535812
Mouse anti-FLAG antibody M2	Sigma Aldrich (F3165) (Lot: SLCJ3741 )	RRID:AB_259529
Mouse IgG	Diaganode (C15400001)	RRID:AB_2722553
Chemicals, peptides, and recombinant proteins
Interferon Gamma (IFNγ)	PeproTech	300–02
Tumor Necrosis Factor Alpha (TNFα)	PeproTech	300-01A-100UG
BAY 11-7085	Med Chem Express	HY-10257
THZ1	Med Chem Express	HY-80013
Triptolide	Med Chem Express	HY-32735
Flavopiridol	Med Chem Express	HY-10005
BMS-345541	Med Chem Express	HY-10519
THZ531	Med Chem Express	HY-103618
Ruxolitinib	Med Chem Express	HY-50856
Vorinostat	Med Chem Express	HY-10221
Trichostatin A	Med Chem Express	HY-15144
dBET6	Med Chem Express	HY-112588
YKL-5-124	Med Chem Express	HY-101257
dCBP-1	Med Chem Express	HY-134582
GNE-781	Med Chem Express	HY-108696
JQ1	Med Chem Express	HY-13030
I-BET151	Med Chem Express	HY-13235
iBET-BD2	Med Chem Express	HY-136571
α-Amanitin	Med Chem Express	HY-19610
Mocetinostat	Med Chem Express	HY-12164
JIB-04	Med Chem Express	HY-13953
I-CBP112	Med Chem Express	HY-19541
iBET-BD2	Med Chem Express	HY-136571
A-366	Med Chem Express	HY-12583
GSK-J1	Med Chem Express	HY-15648
GSK-J4	Med Chem Express	HY-15648B
Cycloheximide	Sigma Aldrich	C4859
A-485	Med Chem Express	HY-107455
AU-15330	Med Chem Express	HY-145388
FHT 2344	Tocris Biotechne	7644/2
AltR S.p. HiFi Cas9 Nuclease V3	IDT	1081061
13C-Thymidine	Cambridge Isotope Laboratories	CLM-3647-PK
15N-Uridine	Cambridge Isotope Laboratories	NLM-812-PK
Biotin-conjugated Concanavalin A	Sigma Aldrich	C2272
Myone Streptavidin T1 DynaBeads	ThermoFisher	65601
Critical commercial assays
Illumina Tagment DNA TDE1 Enzyme and Buffer Kit	Illumina	20034197
Human CXCL9/MIG Quantikine ELISA Kit	Bio-Techne	DCX900
Human CXCL10/IP -10 Quantikine ELISA Kit	Bio-Techne	DIP100
Human CXCL11/I-TAC Quantikine ELISA Kit	Bio-Techne	DCX110
nCounter Standard Master Kit	NanoString	NAA-AKIT-192
nCounter Standard Prep Pack	NanoString	NAA-PPCK-048
nCounter Standard Prep Plates	NanoString	NAA-PPLT-048
nCounter Standard Cartridges	NanoString	NAA-CART-048
8 well chamber slides	Chemglass Life Sciences	CGN-3530-008
Vascular Cell Basal Medium	ATCC	PCS-100-030
Endothelial Cell Growth Kit-VEGF	ATCC	PCS-100-041
ProLong Gold antifade reagent with DAPI	Invitrogen	P36931 Lot: 2501098
Cell Proliferation Kit I (MTT)	Roche	11465007001
Pure-link RNA Mini kit	Invitrogen, ThermoFisher	12183025
NEBNext® Poly(A) mRNA Magnetic Isolation Module	NEB	E7490
NuPage 4–12% Bis Tris 12 well gels	Invitrogen	NP0322BOX
Kaleidoscope Protein ladder	BioRad	1610375
DNA Clean & Concentrator-5	Zymo Research	D4004
Fugene HD	Fugene	HD-1000
TransDux Max	Systems Biosciences	LV860A-1 Lot:230331-003
PEG-IT Virus Precipitation solution	Systems Biosciences	LV825A-1
Universal Mycoplasma Detection Kit	ATCC	30-1012K
iScript RT-qPCR Sample Prep Reagent	Bio-Rad	1708899
iTaq™ Universal SYBR® Green One-Step Kit	BioRad	1725150
Deposited data
ATAC-seq, CUT&RUN, and RNA-seq data	NCBI GEO	GSE232168
Experimental models: Cell lines
TeloHAEC	ATCC (CRL-4052)	RRID:CVCL_Z065
293T/17	ATCC (CRL-11268)	RRID:CVCL_1926
Oligonucleotides
STAT1 cRNA (AGTGGTTAGAAAAGCAAGAC )	IDT	NA
STAT1 cRNA (TTCCCTATAGGATGTCTCAG )	IDT	NA
p65 cRNA (AGCGCCCCTCGCACTTGTAG )	IDT	NA
Alt-R CRISPR-Cas9 Negative Control crRNA	IDT	1072544
Alt-R CRISPR-Cas9 tracrRNA	IDT	1073191
CXCL9 For PCR Primer (GCTGGTTCTGATTGGAGTGC )	IDT	NA
CXCL9 Rev PCR Primer (GAACAGCGACCCTTTCTCAC )	IDT	NA
CXCL10 For PCR Primer (CTGTACGCTGTACCTGCATCA )	IDT	NA
CXCL10 Rev PCR Primer (CAACACGTGGACAAAATTGG )	IDT	NA
CXCL11 For PCR Primer (GAGTGTGAAGGGCATGGCTA )	IDT	NA
CXCL11 Rev PCR Primer (GGGGAAGCCTTGAACAACTG )	IDT	NA
SELE For PCR Primer (GAGGTGCAGCAAGAAGAAGCTTCG )	IDT	NA
SELE Rev PCR Primer (CACTGAAGCCAGGGTCACAC )	IDT	NA
Nol7 For PCR Primer (CGGAAGCGAGAGAAGAGGAG )	IDT	NA
Nol7 Rev PCR Primer (CGCTTCCTCTTCTCCTTCAG )	IDT	NA
HPRT1 For PCR Primer (CTTTGCTGACCTGCTGGA )	IDT	NA
HPRT1 Rev PCR Primer (TGTCCCCTGTTGACTGGT )	IDT	NA
Software and algorithms
Bowtie2	Langmead et al.62	NA
HOMER	Heinz et al.63	NA
MACS2	Zhang et al.64	NA
DESeq2	Love et al.65	NA
Custom NanoString Analysis Code	This study	https://github.com/jonathanbrown484/synergy
Custom GLM Code	This study	https://github.com/jonathanbrown484/synergy
Other
3xFLAG-STAT1 Plasmid	Addgene	220323
3xFLAG-RELA Plasmid	Addgene	220324