Table 1.

Comparison of Overall Incidence and Severity of IPD Cases in the Pre-PCV13 (2007–2010) and Post-PCV13 Vaccine Eras (2011–2019), by Age Group, in Ontario, Canada

	<5 Years	5–49 Years	50–64 Years	≥65 Years	All Ages
No. of cases
Pre-PCV13	437	1144	1087	1806	4474
Post-PCV13	731	2187	2957	4595	10 470
IPD incidence rate (per 100 000)
Pre-PCV13	15.6	3.6	11.0	25.6	8.6
Post-PCV13	11.3	3.0	11.4	23.3	8.4
IPD incidence, RR (95% CI)	0.7 (0.6–0.8)	0.8 (0.8–0.9)	1.0 (1.0–1.1)	0.9 (0.9–1.0)	1.0 (0.9–1.0)
% of cases hospitalized (No.)
Pre-PCV13	68.6 (300)	62.8 (718)	65.6 (718)	70.2 (1267)	67.0 (2998)
Post-PCV13	78.0 (570)	76.9 (1681)	78.8 (2330)	82.3 (3780)	79.9 (8361)
Hospitalization rate (per 100 000)
Pre-PCV13	10.7	2.2	7.2	18.0	5.8
Post-PCV13	8.8	2.3	9.0	19.1	6.7
Hospitalizations, RR (95% CI)	0.8 (0.7–0.9)	1.0 (1.0–1.1)	1.2 (1.1–1.4)	1.1 (1.0–1.1)	1.2 (1.1–1.2)
Case fatality rate, % (No.)
Pre-PCV13	1.4 (6)	5.9 (67)	9.7 (105)	18.8 (340)	11.6 (518)
Post-PCV13	2.3 (17)	5.8 (127)	11.2 (330)	16.4 (755)	11.7 (1229)

Abbreviations: IPD, invasive pneumococcal disease; PCV13, 13-valent pneumococcal conjugate vaccine; RR, rate ratio.