TABLE 2.
GO and KEGG enrichment analysis of the 181 DEmRNAs in lncRNA‐associated ceRNA network.
| Category | Term | Count | Genes | p Value |
|---|---|---|---|---|
| BP | GO:0007268~chemical synaptic transmission | 21 | PRKCG, GABRA1, CHRM1, SLC12A5, GABRA6, HTR1A, HTR2C, CARTPT… | 5.01E‐14 |
| BP | GO:0002181~cytoplasmic translation | 11 | RPS14, RPS15A, RPS16, RPL32, RPS29, RPL27A, RPS3, RPL35A, RPS3A, RPL9, RPL19 | 4.50E‐09 |
| BP | GO:0007187~G‐protein coupled receptor signalling pathway, coupled to cyclic nucleotide second messenger | 7 | CHRM1, HRH3, HTR1A, HTR2C, HTR2A, OPRM1, SSTR3 | 1.81E‐05 |
| BP | GO:0007214~gamma‐aminobutyric acid signalling pathway | 5 | GABRA1, GABRA6, HTR1A, GABRG3, GABRG2 | 8.58E‐05 |
| BP | GO:0031623~receptor internalization | 5 | DNM3, FCER1G, SYK, ITGB2, SNCA | 9.01E‐04 |
| BP | GO:0007269~neurotransmitter secretion | 4 | GRM4, HRH3, STXBP1, SYN2 | 0.002032 |
| BP | GO:0002376~immune system process | 4 | FCGR2A, SYK, CD300A, CD300LF | 0.013619 |
| BP | GO:0034125~negative regulation of MyD88‐dependent toll‐like receptor signalling pathway | 2 | CD300A, CD300LF | 0.016824 |
| BP | GO:0043303~mast cell degranulation | 3 | LAT2, SYK, CPLX2 | 0.01733 |
| BP | GO:1901224~positive regulation of NIK/NF‐kappaB signalling | 4 | CD86, RPS3, LAPTM5, HAVCR2 | 0.022257 |
| MF | GO:0030594~neurotransmitter receptor activity | 10 | GABRA1, CHRM1, HRH3, GABRA6, HTR1A, HTR2C, HTR3B, HTR2A, GABRG3, GABRG2 | 8.03E‐08 |
| MF | GO:0003735~structural constituent of ribosome | 11 | RPS14, RPS15A, RPS16, RPL32, RPS29, RPL27A, RPS3, RPL35A, RPS3A, RPL9, RPL19 | 1.23E‐05 |
| MF | GO:0005230~extracellular ligand‐gated ion channel activity | 5 | GABRA1, GABRA6, HTR3B, GABRG3, GABRG2 | 1.90E‐04 |
| MF | GO:0022851~GABA‐gated chloride ion channel activity | 4 | GABRA1, GABRA6, GABRG3, GABRG2 | 2.14E‐04 |
| MF | GO:0004993~G‐protein coupled serotonin receptor activity | 5 | CHRM1, HRH3, HTR1A, HTR2C, HTR2A | 2.74E‐04 |
| MF | GO:0005249~voltage‐gated potassium channel activity | 5 | KCNH5, KCNC2, KCNS2, KCNAB2, HCN1 | 0.003025 |
| MF | GO:0051378~serotonin binding | 3 | HTR1A, HTR2C, HTR2A | 0.006327 |
| MF | GO:0005516~calmodulin binding | 7 | PPP3R1, KCNH5, RASGRF2, ATP2B3, AKAP5, CAMK1G, CAMKK1 | 0.013354 |
| MF | GO:0031681~G‐protein beta‐subunit binding | 3 | GNG3, GNGT2, OPRM1 | 0.019307 |
| MF | GO:0004712~protein serine/threonine/tyrosine kinase activity | 10 | PRKCG, HIPK4, MAPK9, PAK1, EPHA6, CDKL5, SYK, MAP3K9, CAMK1G, CAMKK1 | 0.022773 |
| CC | GO:0045202~synapse | 33 | CHRM1, RPL32, KCNC2, HTR2C, CPLX2, RPS15A, RPS16, ATCAY… | 5.01E‐18 |
| CC | GO:0005886~plasma membrane | 95 | CD86, RAB3C, GPR26, CHRM1, KCNC2, GPR65, RASGRF2, ITGB2, MS4A7, HTR2C, SIRPB2, HTR2A, RXFP1, CDH9, MS4A4A… | 2.17E‐14 |
| CC | GO:0005887~integral component of plasma membrane | 41 | CHRM1, KCNC2, GPR65, HTR2C, GPR83, HTR2A, PCDH12, TRHDE, RXFP1, CALHM1, GRM4, HRH3… | 3.38E‐11 |
| CC | GO:0045211~postsynaptic membrane | 15 | GABRA1, CHRM1, GABRA6, KCNC2, IQSEC3, HTR3B, HTR2A, OPRM1, GABRG3, CDH9, GABRG2, DDN, GRIN3A, LRRC7, HCN1 | 2.25E‐09 |
| CC | GO:0032590~dendrite membrane | 8 | GABRA1, SLC12A5, GABRA6, KCNC2, AKAP5, OPRM1, GABRG3, GABRG2 | 3.35E‐09 |
| CC | GO:0098978~glutamatergic synapse | 19 | NAPB, CHRM1, CDKL5, SLC30A3, SLC6A17, FRMPD4, STXBP1, ATP2B3, HTR2A, CPLX2, SYN2, C1QL3, GABRG2, DNM3, PPP3R1, GRIN3A, APBA1, DLGAP2, HCN1 | 2.08E‐08 |
| CC | GO:0043005~neuron projection | 17 | GABRA1, TPH2, EPHA6, SLC12A5, SLC30A3, GABRA6, HTR3B, OPRM1, SSTR3, GABRG3, GABRG2, ATCAY, GRIN3A, SV2B, NPBWR1, CPEB3, CAMK1G | 1.45E‐07 |
| CC | GO:0005840~ribosome | 10 | RPS14, RPS15A, RPS16, RPL32, RPS29, RPL27A, RPS3, RPL35A, RPS3A, RPL9 | 1.91E‐05 |
| CC | GO:0030424~axon | 13 | KCNC2, STXBP1, KCNAB2, HTR2A, OPRM1, GABRG2, DNM3, PAK1, ATCAY, SNCG, NEFM, HCN1, SNCA | 7.62E‐05 |
| CC | GO:0098982~GABA‐ergic synapse | 7 | GABRA1, SLC6A17, KCNC2, IQSEC3, ATP2B3, GABRG3, GABRG2 | 9.74E‐05 |
| KEGG | hsa04080:Neuroactive ligand‐receptor interaction | 19 | GABRA1, CHRM1, GABRA6, GLP2R, HTR1A, HTR2C, GPR83, HTR2A, OPRM1, SSTR3, GABRG3, RXFP1, GABRG2, MAS1, GRM4, GRIN3A, HRH3, ADORA3, NPBWR1 | 8.47E‐08 |
| KEGG | hsa04727:GABAergic synapse | 9 | PRKCG, GABRA1, GNG3, GNGT2, SLC12A5, GABRA6, GLS2, GABRG3, GABRG2 | 5.78E‐06 |
| KEGG | hsa03010:Ribosome | 11 | RPS14, RPS15A, RPS16, RPL32, RPS29, RPL27A, RPS3, RPL35A, RPS3A, RPL9, RPL19 | 1.48E‐05 |
| KEGG | hsa05032:Morphine addiction | 8 | PRKCG, GABRA1, GNG3, GNGT2, GABRA6, OPRM1, GABRG3, GABRG2 | 6.30E‐05 |
| KEGG | hsa04726:Serotonergic synapse | 8 | PRKCG, TPH2, GNG3, GNGT2, HTR1A, HTR2C, HTR3B, HTR2A | 2.75E‐04 |
| KEGG | hsa04724:Glutamatergic synapse | 7 | PRKCG, GNG3, PPP3R1, GRM4, GNGT2, GRIN3A, GLS2 | 0.001701 |
| KEGG | hsa04650:Natural killer cell mediated cytotoxicity | 7 | LAT2, PRKCG, PAK1, PPP3R1, FCER1G, SYK, ITGB2 | 0.00281 |
| KEGG | hsa04020:Calcium signalling pathway | 9 | PRKCG, PPP3R1, CHRM1, GRIN3A, FGF9, ATP2B3, HTR2C, HTR2A, CAMK1G | 0.006925 |
| KEGG | hsa04024:cAMP signalling pathway | 7 | MAPK9, PAK1, CHRM1, GRIN3A, HTR1A, ATP2B3, CNGB1 | 0.038778 |
| KEGG | hsa04010:MAPK signalling pathway | 8 | PRKCG, MAPK9, PAK1, PPP3R1, FGF9, RASGRF2, CACNA2D4, MAP3K9 | 0.05 |