TABLE 3.
Functional enrichment analysis of genes that interact with MS4A6A in the PPI network.
| Category | Term | Count | Genes | p Value |
|---|---|---|---|---|
| BP | GO:0007166~cell surface receptor signalling pathway | 3 | CD86, FCGR2A, MS4A7 | 0.0091958 |
| BP | GO:0002224~toll‐like receptor signalling pathway | 2 | TLR8, CTSS | 0.01244988 |
| BP | GO:0032753~positive regulation of interleukin‐4 production | 2 | CD86, FCER1G | 0.01244988 |
| BP | GO:0032703~negative regulation of interleukin‐2 production | 2 | LAPTM5, VSIG4 | 0.01290833 |
| BP | GO:0019886~antigen processing and presentation of exogenous peptide antigen via MHC class II | 2 | FCER1G, CTSS | 0.01474024 |
| BP | GO:0006955~immune response | 3 | CD86, CTSS, C1QC | 0.02089994 |
| BP | GO:0042130~negative regulation of T cell proliferation | 2 | CD86, VSIG4 | 0.022492168 |
| BP | GO:0045087~innate immune response | 3 | FCER1G, TLR8, C1QC | 0.032249129 |
| BP | GO:1901224~positive regulation of NIK/NF‐kappaB signalling | 2 | CD86, LAPTM5 | 0.032443573 |
| BP | GO:0016064~immunoglobulin mediated immune response | 2 | FCER1G, TLR8 | 0.039176889 |
| MF | GO:0019864~IgG binding | 2 | FCGR2A, FCER1G | 0.005792506 |
| CC | GO:0016021~integral component of membrane | 10 | CD86, SLC7A7, FCGR2A, FCER1G, MS4A7, LAPTM5, TLR8, C1ORF162, VSIG4, MS4A4A | 1.84E‐04 |
| CC | GO:0005886~plasma membrane | 8 | CD86, SLC7A7, FCGR2A, FCER1G, MS4A7, LAPTM5, TLR8, MS4A4A | 0.009202711 |
| CC | GO:0009897~external side of plasma membrane | 3 | CD86, FCER1G, TLR8 | 0.02557098 |
| CC | GO:0005887~integral component of plasma membrane | 4 | SLC7A7, FCGR2A, FCER1G, LAPTM5 | 0.036563874 |
| KEGG | hsa05322:Systemic lupus erythematosus | 3 | CD86, FCGR2A, C1QC | 0.00683036 |
| KEGG | hsa05152:Tuberculosis | 3 | FCGR2A, FCER1G, CTSS | 0.011572895 |