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. 2024 Jun 12;20:255. doi: 10.1186/s12917-024-04099-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Estimated marginal means (EMM) of natural log transformed fold change (FC) of fetal DIO2 expression. (A) fetal heart; (B) fetal kidney. Data is grouped by Asn91Ser genotype for the subset of the trial-2 [14]. Fold change was calculated relative to control fetuses from non-inoculated litters and transformed by natural logarithm. Colored dots and associated vertical lines are EMM and 95% confidence interval, respectively. Overlapping gray dots are observed values. 5 CD fetuses deviating over log FC > 1 are highlighted with the dark gray dots in (A). P values for coefficient of genotype are labeled in the plots. Fetal counts in each genotype: (A) CC = 87, CD = 23; (B) CC = 81, CD = 23. Ratio of brain to liver weight (P = 0.001) or brain weight (g) (P = 0.015) included as a covariate in the regression model for heart log FC or kidney log FC, respectively