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. 2024 Jun 12;20:255. doi: 10.1186/s12917-024-04099-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Estimated marginal means (EMM) of fetal growth by Asn91Ser genotype (CC, CD) for each trial (trial-1 [6], trial-2 [14]). Large central dots and associated vertical lines represent the EMM and 95% confidence interval, respectively. Overlapping small dots are raw data. (A) fetal body weight (g); (B) fetal crown rump length (CRL) (cm); (C) fetal brain weight (g); (D) fetal ratio of brain to liver weight. (A, B) The Benjamini-Hochberg (BH) adjusted P values are applied to all possible pairwise comparisons (N = 6) of levels of Asn91Ser and trial and labeled for the genotypic or trial effects at P < 0.10) (C, D) P values for coefficients of genotype or trial are shown in the plots if significant at P < 0.05. Fetal counts in each genotype within each trial: (A, B) CC = 41, CD = 37, in trial-1; CC = 71, CD = 74, in trial-2; (C, D) CC = 26, CD = 24, in trial-1; CC = 47, CD = 59, in trial-2 (1 CD fetus from trial-2 excluded for the ratio of brain to liver weight after residual analyses)