Fig. 6.

Fetal cortisol, T4, and T3 levels in sera by fetal classification and trial. (A) Data from both trials (trial-1 [6] and trial-2 [14]) were merged into each fetal classification. Asn91Ser genotypes were also combined at each level of fetal classification due to lack of significant differences on cortisol levels stratified by trial or fetal classification. Large central dots and associated vertical lines represent median values and equi-tailed two-sided nonparametric 95% confidence intervals, respectively, for each fetal classification. Overlapping small dots are raw data. Different superscripts denote a significant difference in median values between groups, based on Benjamini-Hochberg (BH) adjusted P value < 0.05 from pairwise two-sample permutation tests across groups of fetal classification. (B, C) Fetal observations for cortisol and T4 or T3 level colored by each group of fetal classification with different shapes for trial, respectively. Fetal counts in each level of fetal classification across trials: UNIF = 28, LV-VIA = 25, HV-VIA = 23, HV-MEC = 14