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. 2024 May 7;13(1):2352434. doi: 10.1080/22221751.2024.2352434

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© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 2. — Histological alterations in the skin and immunohistochemical detection of MPXV antigen in one of the infected pigs. (A) Histologic alterations are characterized by epidermal pustule formation (*), hyperplasia of the adjacent epidermis (arrowheads) and superficial perivascular lymphohistiocytic and eosinophilic dermatitis (arrows). The corneal layer of the epidermis was occasionally colonized by coccoid bacteria (dashed arrows). (B) Within this single pustule, sporadic degenerate inflammatory cells contain minimal intracytoplasmic viral antigen (red). No viral antigen was detected within keratinocytes or other cell types. H&E, 200X total magnification; Fast Red, 400X total magnification.