Fig. 1. Dynamics of Ab responses to Wuhan strain after mRNA vaccine.

Analysis of Spike (A and C) or RBD (B and D) binding Abs, ACE2 blocking Abs (E and G), and neutralizing Abs (F and H) to the Wuhan strain between 4 and 9 weeks (T2a) and 19 and 36 weeks (T2b) after dose 2. NV subjects (n = 35) and IV subjects (n = 9) are shown in blue and red dots, respectively. The mean percent decrease in Ab levels and paired t test summary {0.12 [not significant (ns)], 0.0332 [*], 0.0021 [**], 0.0002 [***], and <0.0001 [****]} between the two time points are shown in brackets above the plot. AUC, area under the curve; BAU, binding Ab unity; ID₅₀, 50% inhibitory dose.