Fig. 6. Dynamics of T cell clonal responses before and after the third booster dose.

(A) Analysis of SARS-CoV-2 TCRβ levels at T2a, T2b, and T3 sampling points for LFA-positive and LFA-negative groups. A dotted line representing the threshold for the TCR sequencing assay (2.23) is shown. Analysis of SARS-CoV-2 Spike TCRβ (B) depth and (C) breadth at T2a, T2b, and T3 sampling points for LFA-positive and LFA-negative groups. LFA-positive and LFA-negative groups were classified on the basis of the LFA results of the blood samples collected at T2b. The nonparametric Wilcoxon matched pair set summary is presented within the LFA-positive or LFA-negative groups between sampling time points that are shown in blue brackets above the plot. In addition, the Mann-Whitney summary between the LFA-positive and LFA-negative at the respective sampling time points is shown in black brackets above the plot.