Table 3.
Diet and inflammation-associated disease-relevant pathways.
| Biological Networks | p-value |
|---|---|
| Arthritis (core network) | 0.0014 |
| Breast neoplasm_Metalloproteases | 0.0050 |
| Lupus Erythematosus, Systemic (core network) | 0.0087 |
| Multiple Sclerosis (core network) | 0.0104 |
| Hepatitis (core network) | 0.0383 |
| Breast neoplasm_Inflammatory response | 0.0891 |
| Osteoarthritis (core network) | 0.0930 |
| Breast neoplasm_IL-6 and SP1 | 0.0930 |
| Breast neoplasm_IL-2 and apoptosis | 0.0988 |
| Breast neoplasm_Chemokines | 0.1065 |
| Breast neoplasm_Anti-apoptosis | 0.1387 |
| Diabetes Mellitus, Type 1 (core network) | 0.1609 |
| Lung Neoplasms_Signal transduction | 0.1645 |
| Ovarian Neoplasms (core network) | 0.1897 |
| Fibrosis signaling: common features | 0.2380 |
| TLR signaling in airway epithelium | 0.2530 |
| Pulmonary Fibrosis | 0.2665 |
Biomarker network pathway analysis was performed using GeneGo to associate with diet-dependent inflammation marker differences (see Table 2) between mice fed the high carbohydrate + high fat (HCHF) versus the high protein with higher fiber (HP) diet. IL, Interleukin and Toll-like receptor (TLR).