Table 3.

Diet and inflammation-associated disease-relevant pathways.

Biological Networks	p-value
Arthritis (core network)	0.0014
Breast neoplasm_Metalloproteases	0.0050
Lupus Erythematosus, Systemic (core network)	0.0087
Multiple Sclerosis (core network)	0.0104
Hepatitis (core network)	0.0383
Breast neoplasm_Inflammatory response	0.0891
Osteoarthritis (core network)	0.0930
Breast neoplasm_IL-6 and SP1	0.0930
Breast neoplasm_IL-2 and apoptosis	0.0988
Breast neoplasm_Chemokines	0.1065
Breast neoplasm_Anti-apoptosis	0.1387
Diabetes Mellitus, Type 1 (core network)	0.1609
Lung Neoplasms_Signal transduction	0.1645
Ovarian Neoplasms (core network)	0.1897
Fibrosis signaling: common features	0.2380
TLR signaling in airway epithelium	0.2530
Pulmonary Fibrosis	0.2665

Biomarker network pathway analysis was performed using GeneGo to associate with diet-dependent inflammation marker differences (see Table 2) between mice fed the high carbohydrate + high fat (HCHF) versus the high protein with higher fiber (HP) diet. IL, Interleukin and Toll-like receptor (TLR).