Table 5.

Dietary pattern-differentiated metabolic pathways.

Metabolic pathway perturbed between HCHF vs HP
The Top 10 enriched metabolic pathways	p-value
Thiamine metabolism	0.0410
Fatty acid biosynthesis	0.0879
Biosynthesis of unsaturated fatty acids	0.1042
Glycosphingolipid biosynthesis – ganglio series	0.1448
Lysine degradation	0.1782
Phenylalanine, tyrosine and tryptophan biosynthesis	0.1935
Taurine and hypotaurine metabolism	0.1957
Fatty acid degradation	0.2276
Glutathione metabolism	0.2349
Fatty acid elongation	0.2408

Metabolic pathways were enriched using MetaboAnalyst 5.0 with the mummichog and gene-set enrichment algorithms (GSEA). The listed p-values were calculated by integrating the mummichog and GSEA p-values using Fisher’s method (65, 66). The lower the p-value indicates greater pathway enrichment, even if it is non-significant.