TABLE 2.
Univariate and multivariate cox regression survival analysis of NET patients
| Factor | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI |
P value |
|
| Age at diagnosis | 1.058 | 1.048–1.067 | <0.001* | 1.046 | 1.033–1.060 | <0.001* |
| Gender | ||||||
| Male | Ref | ‐ | ‐ | Ref | ‐ | ‐ |
| Female | 0.630 | 0.498–0.797 | <0.001* | 0.838 | 0.608–1.156 | 0.282 |
| Charlson–Deyo Score | ||||||
| 0 | Ref | ‐ | ‐ | Ref | ‐ | ‐ |
| 1 | 1.713 | 1.285–2.285 | <0.001* | 1.123 | 0.748–1.687 | 0.575 |
| ≥2 | 1.512 | 0.944–2.421 | 0.085 | 0.646 | 0.342–1.219 | 0.177 |
| T Stage | ||||||
| 1 | Ref | ‐ | ‐ | Ref | ‐ | ‐ |
| 2 | 0.976 | 0.630–1.514 | 0.915 | 0.858 | 0.542–1.357 | 0.513 |
| 3 | 1.616 | 1.092–2.393 | 0.016* | 1.052 | 0.685–1.617 | 0.816 |
| 4 | 5.031 | 3.231–7.834 | <0.001* | 3.174 | 1.959–5.144 | <0.001* |
| Surgical margins | ||||||
| Negative | Ref | ‐ | ‐ | Ref | ‐ | ‐ |
| Positive | 3.179 | 2.157–4.684 | <0.001* | 0.690 | 0.428–1.113 | 0.128 |
| Histology | ||||||
| Grade 1 or 2 neuroendocrine tumour | Ref | ‐ | ‐ | Ref | ‐ | ‐ |
| Neuroendocrine carcinoma, NOS | 4.128 | 2.870–5.935 | <0.001* | 2.823 | 1.638–4.864 | <0.001* |
| Large cell neuroendocrine carcinoma | 6.483 | 3.466–12.126 | <0.001* | 2.732 | 1.042–7.165 | 0.041* |
| Small cell neuroendocrine carcinoma | 9.198 | 6.429–13.140 | <0.001* | 5.165 | 2.947–9.051 | <0.001* |
Note: Showing univariate and multivariate Cox regression survival analysis of NET patients. Significance set to p < 0.05 (bolded and * for reference).
Abbreviations: HR, hazard ratio; Ref, reference.