Table 1.
Genes highly expressed in TSCs as compared to myelinating Schwann cells.
| Gene | End organ structure | Method* | Reference |
|---|---|---|---|
| Adgrg6 | NMJ | RNA seq, IHC | [35,127] |
| Agrn | NMJ | RNA seq, WB | [35,128] |
| Ajap1 | NMJ | RNA seq, FISH | [35,38] |
| Apod | NMJ | RNA seq, FISH | [35,38,129] |
| Aqp1 | FNE | IHC | [16] |
| Asic2 | MC, PC | IHC | [79,80] |
| Bche | FNE, MC, NMJ, PC | RNA-seq, IHC, enzymatic activity | [35,75,130,131] |
| Calb1 | MC, PC | IHC | [132] |
| Calb2 | MC, PC | IHC | [132] |
| Chrm5 | NMJ | IHC | [64] |
| Cspg4 (aka NG2) | NMJ | RNA seq, FISH, IHC | [26,32,35,38] |
| Egfr | MC, PC | IHC | [132] |
| Gfap | PC | IHC | [133] |
| Grin2a (aka NMDA2A) | Hair Follicle | IHC | _[59]_ |
| Grm1 | PC | IHC | [83] |
| Kcnj10 (aka Kir4.1) | NMJ | RNA seq, IHC | [35,52] |
| L1cam | FNE | IHC | [134] |
| Mcam (aka CD146) | FNE | IHC | [134] |
| Ncam1 | FNE, MC, NMJ, PC | RNA seq, IHC | [35,54,134,135] |
| Nes | Hair Follicle | IHC | [59,136] |
| Ngfr | FNE, MC,PC | IHC | [53,132,134] |
| Ntrk1 | MC, PC | IHC | [132] |
| P2ry1 | NMJ | RNA seq, IHC | [35,64] |
| Pvalb | MC, PC | IHC | [132] |
| Sema3a | NMJ | RNA seq, IHC | [35,109] |
| Slc17a1 | PC | IHC | [83] |
| Trpv4 | MC | IHC | [78] |
| Ush2a | Hair Follicle, MC | IHC, functional analysis | [84] |
| Vim | FNE, MC, PC | IHC | [54,132,134,137] |
*
RNA seq = RNA sequencing, IHC = immunohistochemistry, WB = western blot, FISH = fluorescence in situ hybridization, NMJ = neuromuscular junction, MC = Meissner corpuscle, PC = Pacinian corpuscle, FNE = free nerve ending.