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. 2024 May 8;630(8016):493–500. doi: 10.1038/s41586-024-07487-w

Fig. 3. Examples of predicted complexes.

Fig. 3

Selected structure predictions from AF3. Predicted protein chains are shown in blue (predicted antibody in green), predicted ligands and glycans in orange, predicted RNA in purple and the ground truth is shown in grey. a, Human 40S small ribosomal subunit (7,663 residues) including 18S ribosomal RNA and Met-tRNAiMet (opaque purple) in a complex with translation initiation factors eIF1A and eIF5B (opaque blue; PDB 7TQL; full-complex LDDT, 87.7; GDT, 86.9). b, The glycosylated globular portion of an EXTL3 homodimer (PDB 7AU2; mean pocket-aligned r.m.s.d., 1.10 Å). c, Mesothelin C-terminal peptide bound to the monoclonal antibody 15B6 (PDB 7U8C; DockQ, 0.85). d, LGK974, a clinical-stage inhibitor, bound to PORCN in a complex with the WNT3A peptide (PDB 7URD; ligand r.m.s.d., 1.00 Å). e, (5S,6S)-O7-sulfo DADH bound to the AziU3/U2 complex with a novel fold (PDB 7WUX; ligand r.m.s.d., 1.92 Å). f, Analogue of NIH-12848 bound to an allosteric site of PI5P4Kγ (PDB 7QIE; ligand r.m.s.d., 0.37 Å).