Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 May 22;630(8016):360–367. doi: 10.1038/s41586-024-07426-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a,b, Schematic illustrations of a non-adhesive implant consisting of a mock device (polyurethane) and a non-adhesive layer (a) and long-term in vivo implantation with fibrous capsule formation at the implant–tissue interface (b). c,d, Schematic illustrations of an adhesive implant consisting of the mock device (polyurethane) and an adhesive layer (c) and long-term in vivo implantation without observable fibrous capsule formation at the implant–tissue interface (d). e–i, Representative histology images stained with Masson’s trichrome (MTS) and haematoxylin and eosin (H&E) for native tissue (left), the adhesive implant (middle) and the non-adhesive implant (right) collected on day 84 post-implantation on the abdominal wall (e), colon (f), stomach (g), lung (h) and heart (i). Black and yellow dashed lines in the images indicate the implant–tissue interface and the fibrous capsule–tissue interface, respectively. The experiment in e–i was repeated independently (n = 4 per group) with similar results. Scale bars, 50 μm (e–g, left and middle; h), 100 μm (e, right; i), 200 μm (f, right), 150 μm (g, right).