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. 2024 May 22;630(8016):360–367. doi: 10.1038/s41586-024-07426-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a, Principal component analysis (PCA) plot illustrating the variances of the adhesive (red dots, n = 4) and non-adhesive (black dots, n = 4) implant-tissue interface dataset collected on day 3 post-implantation to the abdominal wall. b, Volcano plot displaying the gene expression profiles for the non-adhesive and adhesive implant-tissue interfaces collected on day 3 post-implantation to the abdominal wall. Coloured (blue and red) data points represent genes that meet the threshold of fold change (FC) above 1 or under −1, false discovery rate (FDR) < 0.05. Blue and red coloured dots indicate down- and up-regulated genes in the adhesive implant-tissue interface compared to the non-adhesive implant-tissue interface, respectively. c, Top five enriched processes from Gene Ontology (GO) enrichment analysis of differentially expressed genes in the non-adhesive (black) and adhesive (red) implant-tissue interfaces collected on day 3 post-implantation to the abdominal wall. d, PCA plot illustrating the variances of the adhesive (red dots, n = 4) and non-adhesive (black dots, n = 4) implant-tissue interface dataset collected on day 14 post-implantation to the abdominal wall. e, Volcano plot displaying the gene expression profiles for the non-adhesive and adhesive implant-tissue interfaces collected on day 14 post-implantation to the abdominal wall. Coloured (blue and red) data points represent genes that meet the threshold of fold change (FC) above 1 or under −1, false discovery rate (FDR) < 0.05. Blue and red coloured dots indicate down- and up-regulated genes in the adhesive implant-tissue interface compared to the non-adhesive implant-tissue interface, respectively. f, Top five enriched processes from Gene Ontology (GO) enrichment analysis of differentially expressed genes in the non-adhesive (black) and adhesive (red) implant-tissue interfaces collected on day 14 post-implantation to the abdominal wall. The P values were determined by one-sided Fisher’s exact test and adjusted by Storey’s correction method.