Table 1.
Patient profiles 1–10 [24]
| P1–10 | P1 | P2 | P3 | P4 | P5 | P6 | P7 | P8 | P9 | P10 |
|---|---|---|---|---|---|---|---|---|---|---|
| Patient profiles | Postmenopausal luminal A N− | Postmenopausal luminal A N+ | Premenopausal luminal A N− | Premenopausal luminal A N+ | Postmenopausal luminal B Her2− N− | Postmenopausal luminal B Her2− N+ | Premenopausal luminal B Her2− N− | Premenopausal luminal B Her2+ N+ | Postmenopausal Her2+ER/PR- N− | Postmenopausal Her2+ER/PR- N+ |
| Age | 62 | 61 | 50 | 45 | 62 | 58 | 40 | 35 | 58 | 65 |
| Menopause status | Post | Post | Post | Post | Post | Post | Post | Post | Post | Post |
| ECOG | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 2 |
| Previous illness | Bronchial asthma (no long-term therapy, acute therapy with inhaled corticosteroids and formoterol), arterial hypertension (with antihypertensive triple combination of diuretic, calcium antagonist and AT II antagonist) | Hypothyroidism (with L-thyroxine medication) | Relapsing remitting multiple sclerosis (last episode 5 years ago, no long-term medication) | HELLP Syndrome at first pregnancy at age of 34 | Diabetes mellitus type 1, arterial hypertension (with ACE inhibitor medication), hemorrhoids | Crohn’s disease (with continuous therapy with TNF-alpha inhibitors) | Deep vein thrombosis at age 25 while on contraceptive medication, heterozygous factor V Leiden | Colitis ulcerosa, Hashimoto-thyroiditis (with L-thyroxine medication) | COPD GOLD B (with inhaled long-acting muscarinic receptor antagonists and inhaled long-acting ß2 sympathomimetics medication) | Atrial fibrillation (with direct oral anticoagulant and beta-blocker medication), pulmonary artery embolism at the age of 65 following immobilization during right-sided total hip arthroplasty |
| Previous surgical treatment | Transverse laparotomy for hysterectomy because of hypermenorrhea and uterine myomatosus at age of 42, laparoscopic cholecystectomy at the age of 45, open appendectomy at the age of 29 | Open cholecystectomy at the age of 35, breast-conserving tumorectomy for right-sided fibroadenoma at the age of 32, uterine curettage after early abortion at age of 20 | Tonsillectomy in childhood, open appendectomy for complicated appendicitis without free perforation at the age of 27 | Postpartum cardiomyopathy with intensive care ECMO support, Roux-Y gastric bypass for obesity (BMI 50) at the age of 32 | Mamma abscess cleavage on the right side at the age of 35, open hemorrhoidectomy according to Milligan-Morgan at the age of 40 | Bowel-sparing resection for ileum stenosis at the age of 35, open appendectomy at the age of 25, longitudinal laparotomy for mechanical ileus at the age of 55 | Open appendectomy at the age of 28 | Laparoscopy for cyst extirpation of left ovarian cyst at age 30 | none | Right-sided total hip arthroplasty at the age of 65 |
| Birth history | 1 vaginal birth at age of 32, 1 cesarean at the age of 34, 1 early abortion at the age of 30 | 4 vaginal births at the age of 25, 27, 29 and 30, 1 early abortion at the age of 20 | no prior birth | 2 cesareans at the age of 34 and 38 | 4 vaginal births at the age of 18, 20, 28 and 30 | no prior birth | 1 vaginal birth at the age of 39 | no prior birth | 2 vaginal births at the age of 28 and 30 | 2 vaginal births at the age of 23 and 30 and 1 cesarean at the age of 35 |
| Oncologic family history | Maternal aunt with colon cancer at the age of 62 | Maternal female cousin with hodgkin lymphoma at the age of 30 | no prior oncologic family history | Paternal uncle with prostate cancer at the age of 65 | Paternal uncle with colon cancer at the age of 40, paternal grandfather with colon cancer at the age of 60, paternal cousin with colon cancer at the age of 35 | Maternal grandmother with breast cancer at the age of 80 | Sister-in-law with breast cancer at the age of 30 | Paternal grandmother with breast cancer at the age of 70, paternal aunt with breast cancer at the age of 50, maternal uncle with pancreatic cancer at the age of 60 | Maternal grandmother with endometrial cancer at the age of 75, mother with bile duct carcinoma at the age of 60 | Sister with childhood acute lymphoblastic leukemia, father with gastric carcinoma at the age of 50 |
| Previous surgical treatment | BCT+SLN right | BCT+SLN left | BCT+SLN right | BCT+SLN left | BCT+SLN right | BCT+SLN left | BCT+SLN left | BCT+SLN right | BCT+SLN left | MT+SLN right |
| TNM | pT1bN0MX | pT2(2)pN1aM0 | pT1apN0MX | pT1cpN1aM0 | pT3pN0M0 | pT3(3)pN1aM0 | pT2pN0M0 | pT2pN1cM0 | pT1apN0M0 | pT3pN1aM0 |
| Resection margin | R0, 5 mm | R0, 6 mm | R0, 1 mm | R1 on lateral aspect | R0, 0.1 mm | R0, 7 mm | R1 on lateral aspect | R0, 2 mm | R0, 0.05 mm | R0, 10 mm |
| Histologic subtype | NST | Invasive-lobular | Mucinous | NST | Invasive-lobular | NST | Tubular | Invasive-lobular | NST | NST |
| Grading | G1 | G2 | G1 | G2 | G1 | G2 | G2 | G3 | G2 | G2 |
| UL/BL | Unilateral | Unilateral | Unilateral | Unilateral | Unilateral | Unilateral | Unilateral | Unilateral | Unilateral | Unilateral |
| MF/MC | Monofocal and -centric | Monocentric and multifocal, 2 foci | Monofocal and -centric | Monofocal and -centric | Monofocal and -centric | Monocentric and multifocal, 3 foci | Monofocal and -centric | Monofocal and -centric | Monofocal and -centric | Monofocal and -centric |
| ER | 95% | 85% | 95% | 100% | 80% | 75% | 90% | 75% | 5% | 0% |
| PR | 80% | 80% | 90% | 100% | 75% | 90% | 50% | 75% | 1% | 0% |
| Her2 | Negative (IHC 0) | Negative (IHC 1+) | Negative (IHC 0) | Negative (IHC 0) | Negative (IHC 1+) | Negative (IHC 0) | Negative (IHC 2+, ISH negative) | Positive (IHC 3+) | Positive (ISH positive) | Positive (ICH 3+) |
| Ki-67 | 10% | 15% | 8% | 10% | 35% | 28% | 30% | 40% | 20% | 35% |
N ± nodal positive or negative, Her2 ± Her2 positive or negative, BCT breast-conserving tumorectomy, SLN sentinellymphnodectomy, MT mastectomy, UL/BL uni- versus bilaterality, MF/MC multifocality or -centricity, ER estrogen receptor, PR progesterone receptor, Her2 Her2 status, Ki-67 Ki-67-proliferation-index