Table 2.
Patient profiles 11–20 [24]
| P11–20 | P11 | P12 | P13 | P14 | P15 | P16 | P17 | P18 | P19 | P20 |
|---|---|---|---|---|---|---|---|---|---|---|
| Patient profiles | Premenopausal Her2+ER/PR- N− | Premenopausal Her2+ER/PR- N+ | Postmenopausal triple Negative N− | Postmenopausal triple Negative N+ | Premenopausal triple Negative N− | Premenopausal triple Negative N+ | Postmenopausal DCIS, clear resection margin | Premenopausal DCIS, clear resection margin | Postmenopausal DCIS, narrow resection margin | Inflammatory Breast cancer |
| Age | 32 | 42 | 56 | 65 | 29 | 35 | 70 | 38 | 72 | 36 |
| Menopause status | pre | pre | post | post | pre | pre | post | pre | post | pre |
| ECOG | 0 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 1 | 0 |
| Previous illness | Insulin-dependent gestational diabetes during the first pregnancy at the age of 20, postpartum depression at the age of 20 | Pulmonary artery embolism after pelvic vein thrombosis at the age of 26, antiphospholipid syndrome with anti-cardiolipin antibodies (with permanent oral anticoagulation with phenprocoumon) | Insulin-dependent diabetes mellitus type 2, obesity with BMI of 43, obstructive sleep apnea syndrome, secondary arterial hypertension (with ACE inhibitor medication) | Addison’s disease (currently under hydro- and fludrocortisone medication) | none | Paranoid schizophrenia (under stable condition with current olanzapine medication) | Arterial hypertension (with with AT II antagonist medication) | AV-node re-entry tachycardia (with beta-blocker medication) | Chronic lymphocytic leukemia Stadium A | None |
| Previous surgical treatment | None | None | Abdominoplasty at the age of 50, bilateral mammary reduction mammoplasty for mammary hypertrophy at the age of 35 | Total knee replacement on the left side at the age of 50 | None | None | Vaginal hysterectomy with bilateral adnexectomy for uterine prolapse at the age of 55, transcatheter aortic valve implantation due to aortic valve stenosis at the age of 69 | None | Total shoulder arthroplasty on the left side | None |
| Birth history | 1 vaginal birth at the age of 20 | 6 early abortions between the age of 20 and 26 | 3 vaginal births at the age of 20, 21 and 25 | 3 cesareans at the age of 25, 28 and 35 | No prior birth | No prior birth | 2 vaginal births at the age of 16 and 20 | 1 cesarean at the age of 36 | 1 vaginal birth at the age of 22 | No prior birth |
| Oncologic family history | Father with bronchial carcinoma at the age of 60, sister with osteosarcoma at the age of 18 | Father with colon cancer at the age of 45, paternal grandmother with endometrial cancer at the age of 65, paternal uncle with urothelial carcinoma of the renal pelvis at the age of 55 | Mother with breast cancer at the age of 40 | Paternal grandmother with pancreatic cancer at the age of 59, maternal aunt with colon cancer at the age of 60 | Mother with breast cancer at the age of 65, maternal grandmother with breast cancer at the age of 70 | Maternal grandmother with endometrial cancer at age of 60, paternal uncle with rectum carcinoma at the age of 50 | 1 sister with peritoneal cancer at the age of 60, maternal grandmother with ovarian cancer at the age of 65 | Paternal grandfather with prostate cancer at the age of 65, mother with chronic myeloid leukemia at the age of 70 | Father with colon cancer at age 55 | No cancer history |
| Previous surgical treatment | BCT+SLN left | BCT+SLN right | BCT+SLN left | None so far | None so far | None so far | MT right | BCT left and right | BCT+SLN left | None so far |
| TNM | pT2pN0M0 | pT2pN1M0 | pT1apN0M0 | cT3pN+pM1 (OSS) | cT2cN0M0 on left side and cT1bcN0M0 on right side | cT2pN+pM1 (HEP) | pTis (size of the lesion 4.3 cm) | pTis on left and right side (size of the lesions: 2.3 cm on left and 3.2 cm on right side) | pTis (size of lesion 1.5 cm) | cT4dpN+M0 |
| Resection margin | R0, 4 mm | R0, 2 mm | R0, 1 mm | Not applicable | Not applicable | Not applicable | R0, 10 mm | R0, 4 mm on left, 5 mm on right side | R0, 0.01 mm | Not applicable |
| Histologic subtype | NST | NST | NST | NST | NST on left and right side | NST | Not applicable | Not applicable | Not applicable | NST, inflammatory breast cancer with lymphangiosis carcinomatosa |
| Grading | G2 | G3 | G2 | G3 | G3 | G3 | Not applicable | Not applicable | Not applicable | G3 |
| UL/BL | Unilateral | Unilateral | Unilateral | Unilateral | Bilateral | Unilateral | Unilateral | Bilateral | Unilateral | Unilateral |
| MF/MC | Monofocal and -centric | Monofocal and -centric | Monofocal and -centric | Not applicable | Not applicable | Not applicable | Monofocal and multi-centric, 2 centers | Monofocal and -centric on left and right side | Monofocal and -centric | Not applicable |
| ER | 0% | 0% | 0% | 0% | 0% on left and right side | 1% | 95% | 100% on left and right side | 100% | 5% |
| PR | 0% | 5% | 0% | 0% | 0% on left and right side | 2% | 90% | 100% on left and right side | 100% | 5% |
| Her2 | Positive (ICH 3+) | Positive (ISH positive) | Negative (IHC 1+) | Negative (IHC 0) | Negative (IHC 0) on left and right side | Negative (IHC 1+) | Not applicable | Not applicable | Not applicable | Positive (ISH positive) |
| Ki-67 | 65% | 80% | 40% | 60% | 70% left, 85% on right | 80% | Not applicable | Not applicable | Not applicable | 70% |
N ± nodal positive or negative, Her2 ± Her2 positive or negative, BCT breast-conserving tumorectomy, SLN sentinellymphnodectomy, MT mastectomy, UL/BL uni- versus bilaterality, MF/MC multifocality or -centricity, ER estrogen receptor, PR progesterone receptor, Her2 Her2 status, Ki-67 Ki-67-proliferation-index