Fig. 4.

Synteny Analysis of Vertebrate GULO/GULOP Chromosome Regions: Species chromosomes were analyzed for independent chromosome rearrangements. Species order, family, and genera were considered with respect to GULO functionality and orientation when deciding on which species to include for analysis. A Synteny with representative species showing the genetic composition from the NUGGC gene to the STMN4 gene. The synteny is centered around GULO/GULOP. Coloring indicates syntenic blocks (GULOP is colored grey to distinguish it from GULO). B A Fischer’s Exact test was performed to test the hypothesis that the GULO functionality is dependent on the GULO orientation. This test was performed with R, and a p-value of 0.41 was calculated