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. 2024 Jun 12;15:5007. doi: 10.1038/s41467-024-48938-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The red dashed line in each figure represents a country-specific clinically defined cumulative incidence risk threshold for screening. Bootstrapped 95% confidence intervals reflect the uncertainty of the cumulative incidence estimates for the top, median, and bottom of the PGS distribution for a T2D and b breast cancer.