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. 2024 May 30;12:1394064. doi: 10.3389/fchem.2024.1394064

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Copyright © 2024 Leontyev, Pulliam, Ma, Gaul, LaPlaca and Fernández.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ion images for lipids in model. Representative ion images from one brain section besides LPC(O-18:2). The signal for LPC(O-18:2) was weak in the representative section and an image from another section is provided instead. LPC(O-18:2) distribution resembles that of LPC(18:1) but is lower in intensity. H&E-stained section to show anatomy relative to mass spectrometry images. Weak denoising was used. Mass window is ±3 ppm for all images. Step size was 50 μm × 50 µm. The section had 66052 pixels and acquisition time was approximately 23 h. A 2M transient size was used, which is approximately 300,000 mass resolution at m/z 314. All identities were confirmed with LC-MS/MS besides HexCer(42:2; O3) [M + K]⁺ and HexCer(42:1; O3) [M + K]⁺.