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. 2024 May 30;15:1399960. doi: 10.3389/fimmu.2024.1399960

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Copyright © 2024 Olia, Prabhakaran, Harris, Cheung, Gillespie, Gorman, Hoover, Morano, Ourahmane, Srikanth, Wang, Wu, Zhou, Andrews, Kanekiyo, Shapiro, McDermott and Kwong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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L5A7.5 utilizes a different light chain than other MEDI8852 class members, but maintains a similar sequence. (A) Overview of L5A7.5 binding to INDO05 HA. (B) Comparison of CDR L1s of MEDI8852 and L5A7.5 interacting with HA with common residues labeled in black and others in their chain color. (C) Sequence alignment of the light chain germline genes (IGKV1-39, IGKV3-20, IGKV1-9) and their corresponding mature antibodies (MEDI8852, 56.a.09, L5A7.5). CDRs of L5A7.5 are shown above, and the region with significant HA interaction is underlined in yellow.