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Clinical course of patients 1 (ΔHNF3) and 3 (ΔHNF4). Virological parameters (HBV DNA [pg/ml], HBsAg, HBeAg, and anti-HBs) of patient 1 (A) and patient 3 (B) were determined at different time points before and after liver transplantation. The time points are indicated based on the day of OLT, which was set to 0. Sequencing of the HBV DNAs at different time points revealed the dominant DNA strains as indicated. +, present; −, absent; LTx, liver transplantation.
