FIG. 2.

LCMV-induced infiltration of leukocytes into the rejecting allograft. C57BL/6 mice were pretreated with a single donor-specific BALB/c spleen cell transfusion and a brief course of anti-CD154 MAb and then given a BALB/c skin graft as described in Materials and Methods. Mice were either left untreated (A) or infected with LCMV 1 day after transplantation (B and C). (B) The early phase of graft rejection characterized by mononuclear cell infiltration of the epidermal basal layer and hair follicles. This is followed by denudation of the graft (C). (Hematoxylin and eosin stain; magnification, ×160).