TABLE 8.

Clinical trials and clinical applications of experimental approaches to increase ABCG1 expression.

Experimental approach	Clinical trials and applications
ABCG1 overexpression	No human applications found
Extra virgin olive oila	See Oleocanthal/extra virgin olive oil, Table 4
LXR agonists	See Table 4
PPAR-δ activation	See Table 4
RXR activation (Bexarotene)	See Table 4

^aConsumption of extra virgin olive oil for 12 weeks by healthy volunteers increased macrophage expression of ABCG1 (Helal et al., 2013).

The approaches, with the exception of ABCG1 overexpression, are the same as listed for ABCA1 in Table 4. ABCG1 ATP binding cassette subfamily G member 1; LXR, liver X receptor; PPAR-δ, Peroxisome proliferator-activated receptor-delta; RXR, retinoid X receptor.