Table 3.
Hazard ratios (HRs) along with the 95% confidence intervals using multivariate Cox regression models for EFS with prognostic factors including histological response (left), rWIR as a binary variable (middle), and rWIR as a continuous variable (right) as the prognostic factors in a subpopulation of 70 patients without metastases at presentation.
| Factors | HR | 95% CI | Factors | HR | 95% CI | Factors | HR | 95% CI |
|---|---|---|---|---|---|---|---|---|
| Age group | Age group | Age group | ||||||
| Children | Ref | Children | Ref | Children | Ref | |||
| AYA | 1.43 | 0.59–3.46 | AYA | 1.46 | 0.61–3.53 | AYA | 1.28 | 0.53–3.13 |
| Older adults | 2.11 | 0.66–6.79 | Older adults | 2.30 | 0.74–7.21 | Older adults | 2.02 | 0.63–6.50 |
| Tumor size | Tumor size | Tumor size | ||||||
| Small ≤ 8 cm | Small ≤ 8 cm | Small ≤ 8 cm | ||||||
| Large ≥ 8 cm | 1.26 | 0.55–2.92 | Large ≥ 8 cm | 1.33 | 0.60–2.97 | Large ≥ 8 cm | 1.23 | 0.54–2.80 |
| Histological response to CTx | DCE-MRI response (binary) to CTx | DCE-MRI response (continuous) to CTx | 0.69 | 0.50–0.94 | ||||
| Good responder (<10% viable tumor cells) | Good responder (rWIR < 2.3) | |||||||
| Poor responder (≥10% viable tumor cells) | 1.98 | 0.84–4.67 | Poor responder (rWIR ≥ 2.3) | 2.28 | 1.00–5.19 |
HR = hazard ratio; ref = reference category; 95% CI = 95% confidence interval; CTx = chemotherapy; DCE-MRI = dynamic contrast-enhanced magnetic resonance imaging; AYA = adolescents and young adults; and rWIR = relative wash-in rate.