Table 5.

Univariate and multivariate Cox regression analyses evaluating the associations between clinical-histopathological features, including MSI status as determined by ddPCR, and overall survival.

		Univariate			Multivariate
		HR	95% CI	p-Value	HR	95% CI	p-Value
MSI test	MSS	0.324	0.105–0.998	0.046	0.221	0.026–0.870	0.042
	MSI-H
Sex	Male	1.190	0.445–3.115	0.723	3.126	0.296–32.99	0.343
	Female
Age	<67	1.623	0.604–4.636	0.337	2.314	1.576–3.396	0.750
	≥67
Tumor stage	T1/2	0.782	0.528–1.158	0.219	0.587	0.045–3.720	0.428
	T3/4
Node stage	Negative	1.194	0.726–5.043	0.189	0.537	0.045–6.441	0.623
	Positive
Differentiation	Well /moderate	1.073	0.396–2.906	0.890	0.954	0.904–27.981	0.964
	Poor
LVI/PNI	Absent	0.797	0.228–2.787	0.722	1.956	0.050–75.891	0.719
	Present
Adjuvant therapy	No	0.783	0.248–2.496	0.676	2.415	0.184–0.451	0.564
	Yes
Neoadjuvant therapy	No	2.408	0.885–6.701	0.081	2.473	0.056–7.088	0.099
	Yes
MLH1	Normal IHC	0.222	0.050–0.979	0.047	0.133	0.001–1.152	0.049
	Loss of staining
MSH2	Normal IHC	0.466	0.061–3.588	0.464	0.478	0.082–4.719	0.878
	Loss of staining
MSH6	Normal IHC	0.717	0.320–6.268	0.646	0.959	0.341–8.632	0.872
	Loss of staining
PMS2	Normal IHC	0.666	0.190–2.344	0.527	0.744	0.530–9.702	0.490
	Loss of staining

Abbreviations: HR, hazard ratio; CI, confidence interval.