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. 2024 May 27;25(11):5813. doi: 10.3390/ijms25115813

Figure 1.

Figure 1

Mechanical hypersensitivity in a rat model of paclitaxel-induced peripheral neuropathic pain (PIPNP). (A) Experimental protocol for establishing a rat model of PIPNP. Red arrows indicate the administration time of paclitaxel (PTX). (B) Mechanical hypersensitivity indicated by von Frey test in PIPNP. Left: Time course of paw withdrawal threshold (PWT) after PTX or vehicle (Veh) injection. Right: Statistical analysis of the area under the curve (AUC). (C) Percentage of rats with obvious mechanical pain on day 14 after paclitaxel treatment (PWT < 10 g, n = 48). (D) Time course effect and AUC analysis of dynamic score indicated by brush test after PTX or Veh treatment. (E) Time course effect and AUC analysis of paw withdrawal latency (PWL) indicated by Hargreaves test after PTX or Veh injection. (F) Time course effect of cold score indicated by acetone test and its AUC analysis. The data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests for the time course effect. The AUCs were analyzed using an unpaired t-test. * p < 0.05, ** p < 0.01, *** p < 0.001, n = 6 in (B,D,E) n = 5 in (F). All data are means ± SEM.