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. 2024 May 27;25(11):5813. doi: 10.3390/ijms25115813

Figure 3.

Figure 3

Attenuation of paclitaxel-induced mechanical pain by intraperitoneal injection of the TRPV1 antagonist capsazepine (CPZ). (A) Static mechanical hypersensitivity in PIPNP was reduced following intraperitoneal injection of CPZ. Left: Time course of PWT after intraperitoneal injection of CPZ (30 mg/kg) on days 4, 8, 12, and 16 after paclitaxel treatment. n = 11. Right: Statistical analysis of the AUC of PWT from the left panel. (B) Dynamic mechanical allodynia in PIPNP was alleviated by intraperitoneal injection of CPZ. Left: Time course of the dynamic score after intraperitoneal injection of CPZ (30 mg/kg) on days 4, 8, 12, and 16 post-PTX and Veh treatment. n = 6. Right: Statistic analysis of the AUC of the dynamic score from the left panel. The pink areas in left panels of (A,B) indicate the period of making the PIPNP model. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests and an unpaired t-test. ** p < 0.01, *** p < 0.001. ## p < 0.01, ### p < 0.001.