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. 2024 May 27;25(11):5813. doi: 10.3390/ijms25115813

Figure 6.

Figure 6

Activation of TRPM8 significantly attenuated mechanical hypersensitivity in PIPNP. (A,B) Intrathecal injection of 10 μg of WS-12 significantly alleviated both static and dynamic mechanical pain. (A) Time course and statistical analysis of PWT in PTX-treated rats on days 8, 10, 12, and 14 after intrathecal injection of WS-12 or the control. (B) Time course and AUC analysis of the dynamic score in the PTX-treated rats following administration of WS-12 or the control. (C,D) Topical application of 1% menthol demonstrated a significant analgesic effect on paclitaxel-induced mechanical pain. (C) Time course of PWT and AUC analysis in the vehicle-treated, PTX-treated, and PTX treated with menthol application groups on days 7, 14, 21, and 28. (D) Time course and AUC statistical analysis of the dynamic score in the vehicle-treated, PTX-treated, and PTX treated with menthol application groups on days 7, 14, 21, and 28. The pink areas in the left panels of (A–D) indicate the period of making the PIPNP model. The data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests and an unpaired t-test. * p < 0.05, ** p < 0.01, *** p < 0.001, ## p < 0.01, ### p < 0.001. n = 8, 5 in (A); n = 11, 9 in (B); n = 6 in (C) and n = 5 in (D).