Table 3.

Serum levels of RANKL, OPG, LGR4, and RANKL/OPG ratio. Data are represented as median [interquartile range (IQR)]. n, number of rats. ^a p < 0.05, ^aa p < 0.01 versus SHAM NP; ^b p < 0.05, ^bb p < 0.01 versus SHAM HP.

	SHAM NP	SHAM HP	PTX NX NP	PTX NX HP	NX NP	NX HP
n	9	11	8	13	7	8
RANKL (pg/mL) (median [IQR])	18.64 [14.13, 24.79]	25.57 [17.58, 35.09]	64.24 [37.24, 87.16] aa	65.43 [31.92, 75.57] ab	53.76 [53.34, 69.71] aa	64.59 [45.13, 79.83] aab
OPG (pg/mL) (median [IQR])	2568.31 [2093.14, 3684.58]	3024.64 [2405.98, 4888.46]	3394.41 [2653.62, 4045.47]	3438.16 [2478.00, 4160.14]	3032.46 [2860.33, 3329.02]	2815.49 [2183.17, 3021.41]
RANKL/OPG (%)	0.73 [0.50, 0.96]	0.55 [0.36, 1.03]	2.23 [1.32, 2.88] a	1.51 [0.69, 2.63]	1.98 [1.66, 2.42] a	2.95 [1.43, 3.39] aabb
LGR4 (ng/mL) (median [IQR])	3.23 [2.43, 3.75]	2.81 [1.92, 3.10]	3.26 [1.91, 4.94]	4.42 [3.41, 5.49]	3.09 [2.75, 4.20]	3.17 [2.74, 4.40]