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. 2024 May 25;25(11):5751. doi: 10.3390/ijms25115751

Figure 6.

Figure 6

(A) Cartoon illustrating the structure of the photosensitizing supramolecular construct ConA-MB-strep. Biotin-(green)-labeled ConA tetramers (blue) bind MB-(dark red)-labeled streptavidin tetramers (light orange). The interaction between ConA and the saccharides on the surface of the bacterial wall drives the construct to the cellular target, in this example, S. aureus, where photosensitization of reactive oxygen species occurs. Panels (B,C) Light-fluence-dependent PDI of S. aureus and E. coli. (B) Plot of the CFU/mL survival fraction as a function of light-fluence for S. aureus treated with 5 μM ConA-MB-strep (blue circles), 5 μM MB (black), 5 μM MB-strep (green), and untreated (red). (C) Plot of the CFU/mL survival fraction as a function of light fluence for E. coli treated with 5 μM ConA-MB-strep (blue circles), 5 μM MB (black), 5 μM MB-strep (green), and untreated (red). Illumination was obtained with a red lamp (660 ± 10 nm).