Table 1.

Conclusions supporting tumor reversion [2].

“(a) Cancer cells display relevant plasticity, and their fate is not ‘irreversibly’ determined”.

“(b) It is possible to inhibit the phenotypic expression of the malignant characteristics of cancer cells mostly through epigenetic processes, although other mechanisms are likely to participate”. “(c) Depending on the tumor type and stage, some context-dependent conditions/constraints (such as those pertaining to the microenvironment of specific embryogenesis stages) can induce a phenotypic reversion of malignant cancer cells”. “(d) Gene mutations do not play a ‘causative’ role as the somatic mutation theory (SMT) posits, albeit they can be associated throughout the process of cancer development”.