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. 2024 May 28;25(11):5893. doi: 10.3390/ijms25115893

Figure 1.

Figure 1

Summary of information regarding endometrial cancer molecular subtypes. The diagnosis of the molecular subtype is hierarchical according to the PROMISE diagram, with POLE mutation as the dominant determinant even if p53abn status is found. Based on [16,17,21,22,23,24,25]. * NSMP is sometimes considered a subtype associated with poor prognosis [26,27]. DDR—DNA damage response; IHC—immunohistochemistry; MMR—mismatch repair; dMMR—deficiency of mismatch repair; MSI—microsatellite instability; NGS—next-generation sequencing; POLE—DNA Polymerase Epsilon, Catalytic Subunit; NSMP—no specific molecular profile; PD-1—programmed death receptor 1; PD-L1—programmed death-ligand 1.