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| Most Frequent Variants of POLE Gene in Endometrial Cancer | ||
| Protein Change | Nucleotide Substitution | Exon |
| P286R | c.857C>G | 9 |
| V411L | c.1231G>C c.1231G>T |
13 |
| S297F | c.890C>T | 9 |
| A456P | c.1366G>C | 14 |
| S459F | c.1376C>T | 14 |
| Least Frequent Variants of the POLE Gene in Endometrial Cancer | ||
| Protein Change | Nucleotide Substitution | Exon |
| M295R | c.884T>G | 9 |
| F367S | c.1100T>C | 11 |
| D368Y | c.1102G>T | 11 |
| L424I | c.1270C>A | 13 |
| P436R | c.1307C>G | 13 |
| M444K | c.1331T>A | 13 |
