Figure 9.

Autophagy inhibitor chloroquine increases the sensitivity of HT-1080 cells to MIPP and MOMIPP. The HT-1080 cells were incubated for 15 h in the presence of MIPP or MOMIPP (1 μM), with or without chloroquine 60 μM (CQ). Cell viability is presented in panel (A), and the activity of caspase 3/7 is presented in panel (B). Each point represents the mean ± SEM of three independent experiments, each consisting of four replicates per treatment group. The statistical analysis by one-way ANOVA showed significant differences between the groups (α = 0.05) and was followed by Sidak’s multiple comparison test. Data indicated with *** p ≤ 0.001 (versus NT) and ^### p ≤ 0.001 (versus CQ-treated cells) reflect statistically significant differences.