Table 1.
Demographics, respiratory parameters, and chest MRI measurements in ALS patients and healthy controls.
| ALS | HC | p value | |
|---|---|---|---|
| Age | 57.8 ± 12.8 | 56.5 ± 5.7 | 0.119 |
| Sex (M/F) | 5 M; 8 F | 5 M; 6 F | 0.437 * |
| Time onset MRI (months ± SD) | 25.0 ± 17.6 | - | - |
| Time diagnosis MRI (months ± SD) | 19.8 ± 15.5 | - | - |
| FVC (%) ± SD | 59 ± 22 | 97 ± 1.5 | 8.01 × 10−7 |
| FEV1 (%) ± SD | 57 ± 22.2 | 101 ± 4.0 | 8.01 × 10−7 |
| PFC (l/min) ± SD | 173 ± 139 | 459 ± 9.3 | 1.52 × 10−5 |
| ΔAPr (cm) ± SD | 1.1 ± 0.7 | 4.2 ± 0.4 | 8.01 × 10−7 |
| ΔAPl (cm) ± SD | 1.4 ± 0.7 | 4.5 ± 0.9 | 8.01 × 10−7 |
| ΔCCr (cm) ± SD | 2.8 ± 2.0 | 9.0 ± 0.3 | 8.01 × 10−7 |
| ΔCCl (cm) ± SD | 3.2 ± 1.7 | 9.4 ± 0.4 | 8.01 × 10−7 |
| ΔPIarea (cm) ± SD | 4.6 ± 4.2 | 40.2 ± 6.4 | 8.01 × 10−7 |
| ΔPIlenght (cm) ± SD | 4.3 ± 2.3 | 13.6 ± 0.8 | 8.01 × 10−7 |
Abbreviations: forced vital capacity (FVC); forced expiratory volume in the first second (FEV1); peak flow cough (PFC); anteroposterior delta lung on the right (ΔAPr); anteroposterior delta lung on the left (ΔAPl); cranio-caudal delta lung on the right (ΔCCr); cranio-caudal delta lung on the left (ΔCCl); area pulmonary index (ΔPIarea); length pulmonary index (ΔPIlength); SD (standard deviation). Statistical tests: Mann–Whitney, except for *, where we used χ2 test.