Figure 2.

Gene expression differences among pre- and post-chemotherapy patient samples. Stemness scores calculated for all samples (A) and paired tumor samples (B), showing an increase in stemness and mesenchymal features post-chemotherapy. Before chemotherapy samples: 43; after chemotherapy samples: 78. T-test p values are 0.02 and 0.1, respectively. Very limited overlap of USAT identified genes from pre- and post-therapy patient samples, as well as from two other datasets (GSE21653 and GSE25066), showing a dramatic difference in gene expression induced by therapy (C).