Table 1.
Cohort characteristics of 40 patients with locally advanced esophageal squamous cell carcinoma treated with radiotherapy.
| N | % | OS | PFS | |
|---|---|---|---|---|
| p | p | |||
| Age (year) | 0.108 | 0.040 | ||
| ≥65 | 18 | 45.0 | ||
| <65 | 22 | 55.9 | ||
| KPS | 0.019 | 0.014 | ||
| ≥90 | 17 | 42.5 | ||
| <90 | 23 | 57.5 | ||
| Stage (AJCC 6th) | 0.064 | 0.035 | ||
| I–II | 8 | 20.0 | ||
| III–IV | 32 | 80.0 | ||
| Location | 0.392 | 0.128 | ||
| Cervical and upper | 8 | 20.0 | ||
| Middle and lower | 32 | 80.0 | ||
| Length | 0.016 | 0.001 | ||
| ≤5 cm | 18 | 45.0 | ||
| >5 cm | 22 | 55.0 | ||
| Primary tumor volume | 0.019 | 0.007 | ||
| ≤50 cm3 | 18 | 45.0 | ||
| >50 cm3 | 22 | 55.0 | ||
| Therapeutic approach | 0.838 | 0.610 | ||
| RT | 19 | 47.5 | ||
| CRT (Single) | 7 | 17.5 | ||
| CRT (Doublet) | 14 | 35.0 | ||
| Response | 0.566 | 0.758 | ||
| ORR | 20 | 50.0 | ||
| SD | 14 | 35.0 | ||
| PD | 1 | 2.5 | ||
| NA | 5 | 12.5 | ||
| Fold change in miR-143-3p | 0.872 | 0.443 | ||
| ≤1.5 | 27 | 67.5 | ||
| >1.5 | 13 | 32.5 | ||
| Fold change in miR-181a-5p | 0.382 | 0.833 | ||
| ≤1.5 | 19 | 47.5 | ||
| >1.5 | 21 | 52.5 | ||
| Fold change in miR-223-3p | 0.069 | 0.128 | ||
| ≤1.5 | 24 | 60.0 | ||
| >1.5 | 16 | 40.0 | ||
| Fold change in miR-143-3p and miR-223-3p | 0.024 | 0.008 | ||
| Both ≤ 1.5 | 20 | 50.0 | ||
| Any one > 1.5 and both > 1.5 | 20 | 50.0 | ||
| Fold change in miR-143-3p and miR-181a-5p | 0.318 | 0.456 | ||
| Both ≤ 1.5 | 18 | 45.0 | ||
| Any one > 1.5 and both > 1.5 | 22 | 55.0 | ||
| Fold change in miR-181a-5p and miR-223-3p | 0.034 | 0.401 | ||
| Both ≤ 1.5 | 15 | 37.5 | ||
| Any one > 1.5 and both > 1.5 | 25 | 62.5 |