Figure 1.

Schematic representation of the MET receptor (left) and its activation upon ligand interaction, eliciting MET phosphorylation and triggering intracellular signaling responses (right). SEMA: semaphorin domain; blades 1–3 (in red) constitute the α-chain; blades 4–7 (in blue) belong to the β-chain; PSI: plexin–semaphorin–integrin homology domain; IPT 1–4: four immunoglobulin–plexin–transcription factor domains; JM: juxtamembrane domain; TKD: tyrosine kinase domain; DS: docking site. Relevant tyrosine residues (in yellow if phosphorylated) are highlighted.