| 1628 | William Harvey describes the circulation |
| 1785 | William Withering publishes an account of medical use of digitalis |
| 1819 | René Laennec invents the stethoscope |
| 1895 | Wilhelm Röntgen discovers x rays |
| 1920 | Organomercurial diuretics are first used |
| 1954 | Inge Edler and Hellmuth Hertz use ultrasound to image cardiac structures |
| 1958 | Thiazide diuretics are introduced |
| 1967 | Christiaan Barnard performs first human heart transplant |
| 1987 | CONSENSUS-I study shows unequivocal survival benefit of angiotensin converting enzyme inhibitors in severe heart failure |
| 1995 | European Society of Cardiology publishes guidelines for diagnosing heart failure |
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