FIG. 5.

Effect of anti-MIP-2 IgG administration on the survival rate and body weight loss. Infected mice received a total of six intracutaneous injections once daily for six days (indicated by the six arrows below the abscissa) with either 100 μg of anti-protein A IgG (closed circles) (control), 10 μg of anti-MIP-2 IgG (closed triangles), or 100 μg of anti-MIP-2 IgG (closed squares) per day per mouse, and the survival rate (A) and body weight (B) of the mice were monitored. Each point shows the mean ± SD for 10 to 15 mice in each experimental group (SDs indicated by the error bars). An open symbol indicates that the value was significantly different from the control value, with P values of 0.04 (squares) and 0.01 (triangles). The data in panel A were assessed by Fisher's exact probability test, and the data in panel B were assessed by unpaired t test.