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Evolutionary rate and HVR1 immune response. Absence of correlation between evolutionary rate and anti-HVR1 reactivity. Open squares correspond to the reactivity of patient plasma against autologous HVR1 peptides. When two different peptides derived from a patient's quasispecies, two data points are indicated. Diamonds correspond to the number of reactive peptides of each plasma against all extracluster HVR1 peptides divided by the number of peptides tested.
