TABLE 2.
HCV evolutionary rates in different clusters
| Cluster | Donor or recipient | ΔT (yr)a | Mean evolutionary rate (nt substitutions/site/year) (0.63) (10−3) | Statistical significance (P) of difference in evolutionary rateb
|
|
|---|---|---|---|---|---|
| r1 | r2 | ||||
| 1 | d | ? | ? | ? | ? |
| r1 | 5 | 1.14 (0.55) | 0.54 | ||
| r2 | 9.8 | 0.76 (0.29) | |||
| 2 | d | ≈23 | 0.65 (0.17) | 0.026 | 0.012 |
| r1 | 4.4 | 2.10 (0.63) | |||
| r2 | 5.8 | 1.60 (0.34) | |||
| 3 | d | ≈17 | 0.63 (0.23) | 0.14 | |
| r1 | 10.5 | 1.38 (0.46) | |||
| 4 | d | 9 | 0.99 (0.38) | 0.77 | |
| r1 | 8 | 1.14 (0.35) | |||
| 5 | d | ≈17 | 0.34 (0.16) | 2 × 10−12 | 1.3 × 10−5 |
| r1 | 6.6 | 2.73 (0.30) | 0.33 | ||
| r2 | 11.2 | 3.47 (0.70) | |||
| 6 | d | 21 | 0.34 (0.13) | 4 × 10−7 | |
| r1 | 8 | 4.51 (0.81) | |||
a
Interval from the time of sampling to the time of infection.
b
S standard errors are given in parentheses. Calculated by a two-tailed t test with infinite degrees of freedom. Significantly different rates (P < 0.05) are in boldface.